飯島，関谷が 2013年9月にアメリカ，フィラデルフィアにあるトマスジェファーソン医科大学から移動してスタートした新しい研究室です。アルツハイマー病の新規予防治療戦略の確立を目指し，変性たんぱく質によって引き起こされる神経失調，神経細胞死のメカニズムを解明する基礎研究を進めています。一緒に研究してくれる大学院生，博士研究員，技術補佐員を募集しています。 興味のある方は，飯島浩一まで，メールにてお問い合わせください。
学士 (B. S.) 東京大学薬学部 (The University of Tokyo), 1996
博士 (Ph. D.) 東京大学大学院薬学系研究科 (The University of Tokyo), 2001
博士研究員 (Postdoctoral Fellow) Cold Spring Harbor Laboratory, New York, USA, 2001-2006
独立准教授 (Assistant Professor & Laboratory Head) Thomas Jefferson University, Department of Neuroscience, Philadelphia, USA 2006-2013
1. Mendoza, J., Sekiya, M., Taniguchi, T., Iijima, M.K., Wang, R., and Ando, K. (2013) Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro, Journal of Proteome Research, 12(6):2654-65.
2. Iijima-Ando, K., Sekiya, M., Maruko-Otake, A., Ohtake, Y., Suzuki, E., Lu, B., and Iijima, M.K. (2012) Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1, PLoS Genetics, 8(8): e1002918
3. Iijima, K. and Iijima-Ando, K. Transgenic Drosophila models of Alzheimer's amyloid-beta 42 toxicity, (2011) Handbook of Animal Models in Alzheimer's Disease: G. Casadesus (Ed.), IOS Press., 89-106
4. Iijima, K., Gatt, A. and Iijima-Ando, K. (2010) Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease, Hum. Mol. Genet., 19:2947-57. Epub 2010 May 12.
5. Iijima-Ando, K., Zhao, L., Gatt, A., Shenton, C., and Iijima, K. (2010) A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration, Hum. Mol. Genet., 19: 1930-1938
6. Iijima, K., Zhao, L., Shenton, C., and Iijima-Ando, K. (2009) Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila, PLoS ONE, 4(12): e8498
7. Iijima-Ando, K. and Iijima, K. (2009) Transgenic Drosophila models of Alzheimer's disease and tauopathies, (review article), Brain Struct. Funct., 214(2-3):245-62, Epub 2009 Dec 5.
8. Iijima-Ando, K., Hearn, S.A., Shenton, C., Gatt, A., Zhao, L. and Iijima, K. (2009) Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease, PLoS ONE, 4(12): e8310 >>>>> Discussed in Alzforum http://www.alzforum.org/new/detail.asp?id=2358
9. Lee, K-S., Iijima-Ando, K., Iijima, K., Lee, W-J., Lee, J.H., Yu, K., and Lee, D-S. (2009) JNK/FOXO-mediated neuronal expression of fly homologue of Peroxiredoxin II reduces oxidative stress and extends lifespan in Drosophila, J. Biol. Chem., 284, 29454-61
10. Iijima, K., Iijima-Ando, K., and Zhong, Y. (2009) Drosophila model of Alzheimer's amyloidosis, Chapter 14, Handbook of Behavior Genetics, Springer
11. Chiang, H., Iijima, K., Hakker, I., and Zhong, Y. (2009) Distinctive roles of different beta-amyloid 42 aggregates in modulation of synaptic functions. FASEB J, 23(6):1969-77
12. Iijima, K., and Iijima-Ando, K. (2008) Drosophila models of Alzheimer amyloidosis; the challenge of dissecting the complex mechanisms of toxicity of amyloid-beta 42. (Review article) Journal of Alzheimer Disease, 15(4):523-40
13. Iijima-Ando, K., Hearn, S.A., Granger, L., Shenton, C., Gatt, A., Chiang, H.C., Hakker, I., Zhong, Y., and Iijima, K. (2008). Overexpression of Neprilysin Reduces Alzheimer Amyloid beta-42 (Abeta42)-induced Neuron Loss and Intraneuronal Abeta42 Deposits but Causes a Reduction in cAMP-responsive Element-binding Protein-mediated Transcription, Age-dependent Axon Pathology, and Premature Death in Drosophila. J. Biol. Chem. 283, 19066-19076 >>>>> Highlighted by ASBMB
14. Iijima, K., Chiang, H. C., Hearn, S. A., Hakker, I., Gatt, A., Shenton, C., Granger, L., Leung, A., Iijima-Ando, K., and Zhong, Y. (2008) Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila. PLoS ONE 3, e1703
15. Sano, Y., Nakaya, T., Pedrini, S., Furukori, K., Iijima-Ando, K., Iijima, K., Mathews, P.M., Itohara, S., Gandy, S, and Suzuki, T. (2006) Physiological mouse brain amyloid-beta levels are not related to the phosphorylation state of threonine-668 of Alzheimer APP. PLoS ONE, 1, e51
16. Iijima-Ando, K., Wu, P., Drier, A., Iijima, K. & Yin, J.C.P. (2005) CREB and HSP70 additively suppress polyglutamine-induced toxicity in Drosophila. Proc. Natl. Acad. Sci. 102, 10261-6
17. Asaumi, M., Iijima, K., Sumioka, A.,Iijima-Ando, K., Kirino, Y., Nakaya, T. & Suzuki, T. (2005) Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on Abeta secretion. J. Biochem. (Tokyo). 137(2):147-55
18. Iijima, K., Liu, H-P., Chiang, A-S., Hearn, S. A., Konsolaki, M. & Zhong, Y. (2004) Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: A potential model for Alzheimer disease. Proc. Natl. Acad. Sci. 101, 6623-6628 >>>>> Discussed in Alzforum http://www.alzforum.org/new/detail.asp?id=996
19. Taru, H., Iijima, K., Hase, M., Kirino, Y., Yagi, Y., & Suzuki, T. (2002) Interaction of Alzheimer beta-Amyloid Precursor Family Proteins with Scaffold Proteins of the JNK Signaling Cascade. J. Biol. Chem. 277, 20070-78
20. Ando, K., Iijima, K., Elliott, J.L., Kirino, Y., & Suzuki, T. (2001) Phosphorylation-dependent regulation on the interaction of amyloid precursor protein with Fe65 and the production of beta-amyloid. J. Biol. Chem. 276, 40353-61
21. Iijima, K., Ando, K., Takeda, S., Satoh, Y., Seki, T., Itohara, S., Greengard, P., Narin, A.C., Kirino, Y. & Suzuki, T. (2000). Neuron-specific phosphorylation of Alzheimer amyloid precursor protein by Cdk5. J. Neurochem. 75, 1085-91
22. Suzuki, T., Ando, K., Iijima, K., Oguchi, S., Takeda, S. (1999). Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins. Alzheimer's Disease Methods and Protocols, Methods in Molecular Medicine, Vol 32, 271-282
23. Ando, K., Oishi, M., Takeda, S., Iijima, K., Isohara, T., Narin, A.C., Kirino, Y., Greengard, P., & Suzuki, T. (1999). Role of phosphorylation of Alzheimer amyloid precursor protein during neuronal differentiation. J Neurosci. 19, 4421-7
24. Watanabe,T., Sukegawa, J., Sukegawa, I., Tomita, S., Iijima, K., Oguchi, S., Suzuki, T., Nairn, A.C., & Greengard, P. (1999). A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer amyloid precursor protein. J. Neurochem. 72, 549-56
25. Iijima, K, Lee, D.S., Okutsu, J., Tomita, S., Hirashima, N., Kirino, Y., & Suzuki, T. (1998) cDNA isolation of Alzheimer amyloid precursor protein from cholinergic nerve terminals of the electric organ of the electric ray. Biochem. J. 330, 29-33
